In Renaissance Italy, the Borgias were the original crime family. This is the story of the rise of patriarch Rodrigo Borgia to the Papacy, where as Pope Alexander VI, he proceeds to commit every sin in the book to retain power, influence and enormous wealth for himself and his family. But with power comes enemies, who will stop at nothing to see him toppled. As he schemes to destroy his enemies, his mistress Giulia realises her position in the bedroom is precarious; his daughter Lucretia seduces new suitors and brothers Cesare and Juan take sibling rivalry to a whole new level of deviancy. Based on true events.