BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer.

Product information

CAS Number: 850559-51-2

Molecular Weight: 657.33

Formula: C28H25I2N3

Chemical Name: 1-methyl-2-[(E)-2-{6-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]-9H-carbazol-3-yl}ethenyl]pyridin-1-ium diiodide

Smiles: [I-].[I-].C[N+]1=CC=CC=C1/C=C/C1C=C2C(=CC=1)NC1C=CC(=CC=12)/C=C/C1=CC=CC=[N+]1C

InChiKey: KSHYRGPLGVYWRF-UHFFFAOYSA-M

InChi: InChI=1S/C28H24N3.2HI/c1-30-17-5-3-7-23(30)13-9-21-11-15-27-25(19-21)26-20-22(12-16-28(26)29-27)10-14-24-8-4-6-18-31(24)2;;/h3-20H,1-2H3;2*1H/q+1;;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BMVC2 by monitoring the disappearance of the 291 nm CD signals of d[AG3(T2AG3)3] (HT22) after adding Cu2+ is screened, a longer unfolding time would dictate a better G4 stabilizer. The unfolding curve of HT22 in the presence of BMVC2 can be fitted by using two time constants of 133.7 s (29%) and 2816 s (71%), which are similar to the unfolding parameters of BMVC.

Products are for research use only. Not for human use.