Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

Product information

CAS Number: 5578-73-4

Molecular Weight: 367.78

Formula: C20H14ClNO4

Synonym:

Sanguinarin chloride

Sanguinarium chloride

Pseudochelerythrine chloride

Chemical Name: 24-methyl-5, 7, 18, 20-tetraoxa-24-azahexacyclo[11.11.0.0, .0, .0, .0, ]tetracosa-1, 3, 8, 10, 12, 14, 16, 21, 23-nonaen-24-ium chloride

Smiles: [Cl-].C[N+]1=CC2=C3OCOC3=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12

InChiKey: GIZKAXHWLRYMLE-UHFFFAOYSA-M

InChi: InChI=1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Han MH, et al.Toxicol Lett. 2013 Jul 4;220(2):157-66.

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