THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 146395-14-4

Molecular Weight: 322.39

Formula: C15H30O7

Chemical Name: 14-(oxan-2-yloxy)-3,6,9,12-tetraoxatetradecan-1-ol

Smiles: OCCOCCOCCOCCOCCOC1CCCCO1

InChiKey: ZEGHHDSVKRWOCB-UHFFFAOYSA-N

InChi: InChI=1S/C15H30O7/c16-4-6-17-7-8-18-9-10-19-11-12-20-13-14-22-15-3-1-2-5-21-15/h15-16H,1-14H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.