Claudin-11 (S198) Polyclonal Antibody

Catalogue Numbers: BS1065-50, BS1065-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75508

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteinsare known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Claudin 11 (S198) polyclonal antibody detects endogenous levels of Claudin 11 protein.

Extra Notes: Western blot (WB) analysis of Claudin-11 (S198) polyclonal antibody at 1:500 dilution
Lane1:Hela cell lysate
Lane2:Raw264.7 cell lysate
Lane3:Rat heart tissue lysate

Bioworld Molecular Weight: ~ 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CLDN11; CLAUDIN-11; OSP; OTM; Claudin 11; Claudin11

Immunogen: Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-11.

Conjugate: Unconjugated

Modification: Unmodified